ISSN 1662-4009 (online)

ey0018.12-2 | Type 2 Diabetes | ESPEYB18

12.2. Identification of pathognomonic purine synthesis biomarkers by metabolomic profiling of adolescents with obesity and type 2 diabetes

J Concepcion , K Chen , R Saito , J Gangoiti , E Mendez , ME Nikita , BA Barshop , L Natarajan , K Sharma , JJ Kim

PLoS One. 2020 Jun 26;15(6):e0234970. doi: 10.1371/journal.pone.0234970.In brief: Metabolite signatures were compared between children with normal weight, obesity, and both obesity and T2DM, by measuring 273 analytes in fasting plasma and a 24-hour urine sample. Twenty-two urine metabolites were uniquely associated with T2DM. Adolescents with T2DM have altered purine nucleoti...

ey0015.15-12 | Obesity must be studied separately in men and women | ESPEYB15

15.12 TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

C Wang , Y He , P Xu , Y Yang , K Saito , Y Xia , X Yan , A Hinton Jr , C Yan , H Ding

To read the full abstract: Nature Communications 2018;9:1544Obesity prevalence is generally higher in women than in men, and there is also a sex difference in body fat distribution. Sex differences in obesity can be explained in part by the influence of gonadal steroids on body composition and appetite; however, behavioural, and socio-cultural factors may also play a role. Here is th...

ey0021.9-15 | Growth Problems in Cancer Survivors | ESPEYB21

9.15. Association between conditioning intensity and height growth after allogeneic hematopoietic stem cell transplantation in children

S Uemura , D Hasegawa , K Kishimoto , T Fujikawa , S Nakamura , A Kozaki , A Saito , T Ishida , T Mori , K Ozaki , Y Kosaka

Brief Summary: This retrospective, single-center study from Kobe Children’s Hospital, Japan, analyzed height SDS (main outcome) and risk of short stature (height <-2 SDS, secondary outcome) in 89 children with malignant diseases who underwent initial allogenic hematopoietic stem cell transplantation (HSCT) with different conditioning intensities. More intensive conditioning conferred a substantially higher risk of short stature at 3 years after HSCT.<p class="abst...

ey0016.5-19 | Basic Science - Mineral Metabolism | ESPEYB16

5.19. Eldecalcitol causes FGF23 resistance for Pi reabsorption and improves rachitic bone phenotypes in the male Hyp mouse

I Kaneko , H Segawa , K Ikuta , A Hanazaki , T Fujii , S Tatsumi , S Kido , T Hasegawa , N Amizuka , H Saito , KI Miyamoto

Abstract: Endocrinology, Volume 159, Issue 7, July 2018, Pages 2741–2758In brief: Eldecalcitol, a long acting active vitamin D3 analogue with lower affinity for vitamin D receptor and resistance to inactivation by vitamin D 24-hydroxylase, causes FGF23 resistance. This leads to complete restoration of renal phosphate transport and NaPi-2a protein levels and improves ra...

ey0020.3-17 | Advances in Growth, Bone Biology, and Mineral Metabolism | ESPEYB20

3.17. Nutrient-regulated dynamics of chondroprogenitors in the postnatal murine growth plate

T Oichi , J Kodama , K Wilson , H Tian , Y Imamura Kawasawa , Y Usami , Y Oshima , T Saito , S Tanaka , M Iwamoto , S Otsuru , M Enomoto-Iwamoto

In Brief: The authors use cell-tracing of Axin2-positive chondroprogenitor cells in the resting zone during and after food restriction to demonstrate that nutrient availability influences the balance between accumulation and differentiation of resting zone chondrocytes and that this is influenced by Igf-1.Commentary: Catch-up growth is the rapid growth that occurs after growth-inhibiting conditions have been cured or removed. The molecular mechanism for ...

ey0016.11-3 | New Insights into Body Weight Regulation | ESPEYB16

11.3. Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis

Y Yang , AA van der Klaauw , L Zhu , TM Cacciottolo , Y He , LKJ Stadler , C Wang , P Xu , K Saito , A Jr. Hinton , X Yan , JM Keogh , E Henning , MC Banton , AE Hendricks , EG Bochukova , V Mistry , KL Lawler , L Liao , J Xu , S O'Rahilly , Q Tong , UK10K Consortium , I Barroso , BW O'Malley , IS Farooqi , Y Xu

To read the full abstract: Nat Comm 2019; 10(1): 1718Steroid receptor coactivator (SRC)-1 mediates nuclear hormone receptors and transcription factor-dependent transcription (1), and interacts with STAT3 (2) an important mediator of leptin-induced POMC expression and hence satiety (3). Src-1 knockout mice are obese (4), however, the underlying mechanism is unclear. In a...