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8.18 PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal

T Dumontet , I Sahut-Barnola , A Septier , N Montanier , I Plotton , F Roucher-Boulez , V Ducros , AM Lefrançois-Martinez , JC Pointud , M Zubair , KI Morohashi , DT Breault , P Val , A Martinez

To read the full abstract: JCI Insight. 2018;3(2). pii: 98394The (human) adrenal cortex undergoes massive changes in structure and function from fetal to postnatal life, with the first consisting of a small outer definitive zone and a larger inner fetal zone, and the latter finally consisting of three distinct layers, namely the zona glomerulosa (ZG), fasciculata (ZF) and reticularis (ZR). Ho...

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ey0016.8-3 | New Mechanisms | ESPEYB16

8.3. Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex

M Mathieu , C Drelon , S Rodriguez , H Tabbal , A Septier , C Damon-Soubeyrand , T Dumontet , A Berthon , I Sahut-Barnola , C Djari , M Batisse-Lignier , JC Pointud , D Richard , G Kerdivel , MA Calmejane , V Boeva , I Tauveron , AM Lefrancois-Martinez , A Martinez , P Val

To read the full abstract: Proc Natl Acad Sci USA. 2018; 115(52): E12265E12274.The adrenal cortex plays a central role in regulating body homeostasis through the production of glucocorticoids and mineralocorticoids that control many important physiologic functions, such as metabolism, inflammation and arterial blood pressure. The production of these hormones, known as steroid...

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ESPE Yearbook of Paediatric Endocrinology

8.18 PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal

8.3. Steroidogenic differentiation and PKA signaling are programmed by histone methyltransferase EZH2 in the adrenal cortex

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