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1.10 The versatile tanycyte: a hypothalamic integrator of reproduction and energy metabolism

V Prevot , B Dehouck , A Sharif , P Ciofi , P Giacobini , J Clasadonte

To read the full abstract: Endocr Rev 2018;39:3,333This review is interesting for several reasons. It focuses on a specific type of cells lining the wall of the third ventricle in the median eminence of the hypothalamus. This region acts both as a secretor of neuropeptides and as a sensor of the metabolic status of the periphery. These two functions imply a bidirectional physiological pathway: br...

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ey0019.7-11 | Basic Science | ESPEYB19

7.11. Selective depletion of adult GFAP-expressing tanycytes leads to hypogonadotropic hypogonadism in males

L Butruille , M Batailler , ML Cateau , A Sharif , V Leysen , V Prevot , P Vaudin , D Pillon , M Migaud

Front Endocrinol (Lausanne). 2022 Mar 16;13:869019. doi: 10.3389/fendo.2022.869019. PMID: 35370973. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966543/Brief Summary: This mouse study explores the function of alpha-tanycytes, which are neurogenic stem cells located in the medio-basal hypothalamus and expres...

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ey0019.7-8 | Basic Science | ESPEYB19

7.8. GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation

G Pellegrino , M Martin , C Allet , T Lhomme , S Geller , D Franssen , V Mansuy , M Manfredi-Lozano , A Coutteau-Robles , V Delli , S Rasika , D Mazur , A Loyens , M Tena-Sempere , J Siepmann , FP Pralong , P Ciofi , G Corfas , AS Parent , SR Ojeda , A Sharif , V Prevot

Nat Neurosci. 2021 Dec;24(12):1660-1672. doi: 10.1038/s41593-021-00960-z. Epub 2021 Nov 18. PMID: 34795451. https://www.nature.com/articles/s41593-021-00960-zBrief Summary: This neuroanatomical and physiological study in mice demonstrates that GnRH neurons attract glial cells in their vicinity via cellcell communication...

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ey0015.7-8 | Genetic architecture of hypogonadotropic hypogonadism and delayed puberty | ESPEYB15

7.8 Congenital hypogonadotropic hypogonadism and constitutional delay of growth and puberty have distinct genetic architectures

D Cassatella , SR Howard , JS Acierno , C Xu , GE Papadakis , FA Santoni , AA Dwyer , S Santini , GP Sykiotis , C Chambion , J Meylan , L Marino , L Favre , J Li , X Liu , J Zhang , PM Bouloux , C Geyter , A Paepe , WS Dhillo , JM Ferrara , M Hauschild , M Lang-Muritano , JR Lemke , C Flück , A Nemeth , F Phan-Hug , D Pignatelli , V Popovic , S Pekic , R Quinton , G Szinnai , D l'Allemand , D Konrad , S Sharif , ÖT Iyidir , BJ Stevenson , H Yang , L Dunkel , N Pitteloud

To read the full abstract: Eur J Endocrinol. 2018 Apr;178(4):377-388[Comments on 7.7 and 7.8] Familial self-limited delayed puberty is highly heritable and has a clear genetic basis as described in the review written by Sasha Howard. Recent studies suggest that the genetic basis of self-limited delayed puberty is likely to be highly heteroge...

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ESPE Yearbook of Paediatric Endocrinology

1.10 The versatile tanycyte: a hypothalamic integrator of reproduction and energy metabolism

7.11. Selective depletion of adult GFAP-expressing tanycytes leads to hypogonadotropic hypogonadism in males

7.8. GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation

7.8 Congenital hypogonadotropic hypogonadism and constitutional delay of growth and puberty have distinct genetic architectures

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