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ey0019.11-14 | Weight regulation and endocrine circuits (including interventions) | ESPEYB19

11.14. Energy balance in hypothalamic obesity in response to treatment with a once-weekly GLP-1 receptor agonist

A Shoemaker , H Silver , M Buchowski , J Slaughter , J Yanovski , C Elfers , C Roth , MJ Abuzzahab

Ashley.H.Shoemaker@VUMC.org International Journal of Obesity 2022, Epub 2022 Jan 3. doi: 10.1038/s41366-021-01043-6. https://pubmed.ncbi.nlm.nih.gov/34975146/Brief Summary: This double-blind, placebo-controlled trial assessed the efficacy of 36 weeks of GLP1RA treatment with exenatide e...

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ey0021.11-4 | Interventions for Weight Loss: New Findings | ESPEYB21

11.4. Setmelanotide for the treatment of acquired hypothalamic obesity: a phase 2, open-label, multicentre trial

CL Roth , C Scimia , AH Shoemaker , M Gottschalk , J Miller , G Yuan , S Malhotra , MJ Abuzzahab

Brief Summary: This phase 2, open-label, multicenter trial examined the efficacy of setmelanotide, a melanocortin-4 receptor agonist, in patients aged 6 to 40 years with obesity due to hypothalamic injury. Setmelanotide reduced body mass index (BMI) and hunger levels in most participants; 89% achieved a reduction in BMI of at least 5% after 16 weeks. These results indicate that setmelanotide is a promising treatment for hypothalamic obesity.This phase 2 ...

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ey0020.10-2 | New Data on the Epidemiology of T2D in Children | ESPEYB20

10.2. The Coronavirus Disease 2019 pandemic is associated with a substantial rise in frequency and severity of presentation of youth-onset type 2 diabetes

SN Magge , RM Wolf , L Pyle , EA Brown , VC Benavides , ME Bianco , LC Chao , A Cymbaluk , PG Balikcioglu , K Halpin , DS Hsia , L Huerta-Saenz , JJ Kim , S Kumar , LE Levitt--Katz , BE Marks , A Neyman , KL O'Sullivan , SS Pillai , AS Shah , AH Shoemaker , JAW Siddiqui , S Srinivasan , IH Thomas , JB Tryggestad , MF Yousif , MM Kelsey , COVID-19 and Type 2 Diabetes Consortium Kelsey

Brief summary: A significant increase in the incidence T2D occurred in the USA during the COVID-19 pandemic, particularly among children with obesity and males.Comment: This is the first multicenter report on the incidence of T2D during the first year of the COVID-19 pandemic in the USA. The average number of new diagnoses per year in the two pre-pandemic years was 825, compared with 1463 during the first pandemic year. This increase of 77% is significan...

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ey0016.14-15 | (1) | ESPEYB16

14.15. Recovery of trait heritability from whole genome sequence data

Wainschtein Pierrick , Jain Deepti P , Yengo Loic , Zheng Zhili , Anthropometry Working Group TOPMed , for Precision Medicine Consortium Trans-Omics , Cupples L Adrienne , Shadyab Aladdin H , McKnight Barbara , Shoemaker Benjamin M , Mitchell Braxton D , Psaty Bruce M , Kooperberg Charles , Roden Dan , Darbar Dawood , Arnett Donna K , Regan Elizabeth A , Boerwinkle Eric , Rotter Jerome I , Allison Matthew A , McDonald Merry-Lynn N , Chung Mina K , Smith Nicholas L , Ellinor Patrick T , Vasan Ramachandran S , Mathias Rasika A , Rich Stephen S , Heckbert Susan R , Redline Susan , Guo Xiuqing , Chen Y-D Ida , Liu Ching-Ti , Andrade Mariza de , Yanek Lisa R , Albert Christine M , Hernandez Ryan D , McGarvey Stephen T , North Kari E , Lange Leslie A , Weir Bruce S , Laurie Cathy C , Yang Jian , Visscher Peter M

bioRxiv March 25, 2019. doi: https://doi.org/10.1101/588020The Yearbook does not usually report on studies that are yet published only on preprint servers, i.e. author-deposited versions of papers that have not been accepted or even peer-reviewed. However, Nature also made an exception for this paper (1)!These authors analysed whole genome sequen...

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ESPE Yearbook of Paediatric Endocrinology

11.14. Energy balance in hypothalamic obesity in response to treatment with a once-weekly GLP-1 receptor agonist

11.4. Setmelanotide for the treatment of acquired hypothalamic obesity: a phase 2, open-label, multicentre trial

10.2. The Coronavirus Disease 2019 pandemic is associated with a substantial rise in frequency and severity of presentation of youth-onset type 2 diabetes

14.15. Recovery of trait heritability from whole genome sequence data

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