ESPE Yearbook of Paediatric Endocrinology

Endocrinology 163, bqac005. (2022).Abstract: https://pubmed-ncbi-nlm-nih-gov/35041746/In Brief: C-type natriuretic peptide (CNP) is known to stimulate enchondral bone formation, but the distinct cellular pathways and cellular targets are unclear. This study used in vivo and in vitro biosensor systems to identify cGMP-induced activation of PKA as a major effect of CNP with growth promoting e...

To read the full abstract: Pediatrics. 2018 Apr;141(4)See comment on 6.8....

In Brief The authors report a genome-wide association study (GWAS) on Type 2 diabetes (T2D), including data from 2 535 601 individuals (39.7% non-European ancestry), including 428 452 with T2D. They identify 1,289 independent GWAS signals (at P < 5×10−8), of which 145 loci are novel. These genetic signals cluster into 8 groups, with differing cardiometabolic trait associations and differing cell-specific profiles of gene activation (open chro...

J Clin Endocrinol Metab. 2022; 107(6): 1679-1685. PMID: 35254428https://pubmed.ncbi.nlm.nih.gov/35254428/Brief Summary: This review summarizes the evidence on the potential benefits and risks of androgen prohormones, such as dehydroepiandrosterone (DHEA), in normal women and those with DHEA-deficient states.Physiologically, the concentrations of DHEA and DHEAS increase...

rakeshkgyl@gmail.com J Pediatr Hematol Oncol. 2022; 44: e469-e473. PMID: 34054040.Brief Summary: This monocentric, retrospective study investigated adrenal insufficiency (AI) prevalence in a large group of children with brain tumors (BT, 398 patients) and children treated with hematopoietic cell transplantation (HCT, 268 patients). AI was diagnosed in 14 BT patients (27.4% of the 51 tested) and 14 HCT re...

To read the full abstract: Diabetes Care. 2019 Jun;42(6):1009–1017. PMID: 30967436Gestational diabetes mellitus (GDM) is increasing in incidence, affecting approximately 14% of pregnancies. Preventing GDM may significantly improve outcome for both mothers and offspring. The pathogenesis of GDM involves insulin resistance, pancreatic beta-cell failure and an increase in inflamm...

To read the full abstract: Nature Communications 2018;9:636We know that good nutrition early in life has profound and long-lasting effects on body weight in later life. Malnutrition during pregnancy or infant formula feeding may be stored on the offspring genome as epigenetic memory and persist into adulthood, thereby influencing the susceptibility to metabolic diseases, such as obes...

To read the full report: https://www.fda.gov/NewsEventsThe report, issued by the U.S. National Toxicological Program (NTP), presents the initial results of a multimillion dollar study conducted for more than 5 years by scientists at FDA’s National Center for Toxicological Research. It looked at the effects of different doses of BPA evaluating chronic and e...

Front Endocrinol (Lausanne). 2022 Mar 24;13:832678. doi: 10.3389/fendo.2022.832678. PMID: 35399939.Brief Summary: This retrospective case note study assessed the impact of different classes of obesity on maternal and neonatal outcomes. Higher classes of maternal obesity were associated with increased rates of caesarean section, GDM and gestational hypertension and pre-eclampsia.<p class...

Preface: A PubMed search for “Medicine and Science” limited to the last 12 months will return 303 153 hits, and if filtered for reviews 38 153. These numbers change to 802 and 127, respectively, when the search is performed with the term “Science and Medicine”. This shows that it is exceedingly difficult to search for “the” most important articles to provide in this chapter. Thus we have taken a different approach, by asking members of the team of...