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ey0019.15-17 | Basic Science and Genetics | ESPEYB19

15.17. Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2

Krishnan K Chella , L Vergnes , R Acin-Perez , L Stiles , M Shum , L Ma , E Mouisel , C Pan , TM Moore , M Peterfy , CE Romanoski , K Reue , JLM Bjorkegren , M Laakso , M Liesa , AJ Lusis

Nat Metab. 2021;3(11):1552-68. doi: 10.1038/s42255-021-00481-w.PubMed ID: 34697471Brief summary: This study identified a genetic locus on mouse chromosome 17, containing the gene Ndufv2, that controls mitochondrial mass and function in adipose tissue in a sex- and tissue-specific manner. In female mice, Ndufv2 regulated the expression of 89 mitochondrial genes, with invol...

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ey0016.12-14 | Lipid Metabolism | ESPEYB16

12.14. An integrative systems genetic analysis of mammalian lipid metabolism

BL Parker , AC Calkin , MM Seldin , MF Keating , EJ Tarling , P Yang , SC Moody , Y Liu , EJ Zerenturk , EJ Needham , ML Miller , BL Clifford , P Morand , MJ Watt , RCR Meex , KY Peng , R Lee , K Jayawardana , C Pan , NA Mellett , JM Weir , R Lazarus , AJ Lusis , PJ Meikle , DE James , TQ de Aguiar Vallim , BG Drew

Nature 2019;567:187193.URL https://doi.org/10.1038/s41586-019-0984-ySummary: Novel diagnostic and prognostic biomarkers in the blood that can predict early fatty liver disease were identified, using a proteomic and lipidomic-wide systems genetic approach in 107 genetically distinct mouse strains. In addition, the novel lipid-regulatory protein, PSMD9, was identified as...

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ESPE Yearbook of Paediatric Endocrinology

15.17. Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2

12.14. An integrative systems genetic analysis of mammalian lipid metabolism

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