ESPE Yearbook of Paediatric Endocrinology

J Clin Endocrinol Metab. 2021 Nov 19;106(12):e5075-e5087. doi: 10.1210/clinem/dgab528. PMID: 34272865.Brief Summary: This national birth registry study in Denmark collected data on gestational diabetes and adverse pregnancy outcomes in relation to country of origin of the mother. Country of origin and the number of births were associated with adverse effects from gestational diabetes.<p cl...

J Clin Endocrinol Metab. 2018 Aug 1;103(8):3028–3037.doi: 10.1210/jc.2018-00482. PubMed ID: 29917083Minipuberty is a poorly understood developmental event at 1–6 months of age, during which the hypothalamic-pituitary-gonadal axis is transiently activated.This study assessed serum reproductive hormone concentrations in 1840 healthy boys ...

To read the full abstract: Journal of clinical endocrinology and metabolism vol. 105,3 (2020):754–768. doi: https://academic.oup.com/jcem/article/105/3/754/5624050The authors used state-of-the-art liquid chromatography tandem mass spectrometry to establish sex-specific reference ranges for estrone (E1) and estradiol (E2) throughout life and evaluate sex-differences.</...

To read the full abstract: J Assist Reprod Genet. 2018 Jul; 35(7):1209.Galactosemia is an autosomal recessive genetic disorder of the galactose metabolism, caused by impaired activity of galactose-1-phosphate uridyltransferase (GALT). Complete deficiency or severely reduced activity of GALT affects approximately 1:30,000 to 1:50,000 persons. Girls and women with classic galactosemia have...

Adult Life After Childhood Cancer in Scandinavia Study Groupkenborg@cancer.dk Cancer 2021; 127: 3881-3892. PMID: 34297360.Brief Summary: This register-based cohort study analysed the likelihood of live birth among female childhood cancer survivors (CCSs) diagnosed in between 1943 and 2006, in comparison with the general population. The prevalence of first live birth was lower in CCSs compared to matched con...

To read the full abstract: Diabetes Care. 2017;40:920-927Breast feeding has been identified as one albeit weak protective factor protecting from the development of for example obesity, autoimmune disease and in particular T1DM. The mechanisms of this preventive effect are not known. One explanation might still be a confounding effect of social status, overall healthy lifestyles in the families in who...

Cell Rep Med. 2022;3(1):100477. doi: 10.1016/j.xcrm.2021.100477. PubMed ID: 35106505Brief summary: To explore clinical heterogeneity, this study analyzed baseline visit data on 726 adults with newly diagnosed Type 2 diabetes (T2D) adults and identified in 4 distinct profiles (clusters of phenotypes), which predicted differences in subsequent disease progression and anti-diabetic treatments...

In Brief: The authors describe a wide range of studies. Firstly, observational studies showed that circulating taurine concentrations decline with age in mice, monkeys, and humans – and in the latter, low taurine was associated with metabolic disease (abdominal fat, blood pressure, Type 2 diabetes). They then gave oral taurine to mice throughout their lives and showed that this increased lifespan by 10–12% and improved functional outcomes of almost all tissues studie...

To read the full abstract: PLoS Med, 2019;16:e1002744These investigators painstakingly collated individual-level data from 37 pregnancy and birth cohort studies from Europe, North America, and Australia, comprising 162,129 mothers and their children, in order to identify the optimal levels gestational weight gain in relation to risk of offspring obes...