ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

Page 1 of about 3 results

ey0017.8-13 | New Concerns | ESPEYB17

8.13. Adverse childhood experiences, DNA methylation age acceleration, and cortisol in UK children: a prospective population-based cohort study

Tang Rosalind , Howe Laura D , Suderman Matthew , Relton Caroline L , Crawford Andrew A , Houtepen Lotte C

To read the full abstract: Clin Epigenetics. 2020; 12: 55. PMID: 32264940.A large body of evidence has documented the long-term consequences of adverse childhood experiences (ACEs) on social and health outcomes in later life (1). However, the underlying mechanisms remain unclear. Epigenetic mechanisms may explain the lasting effects of early life adversity (2</stron...
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ey0016.15-4 | (1) | ESPEYB16

15.4. Association of long-term child growth and developmental outcomes with metformin vs insulin treatment for gestational diabetes

SN Landi , S Radke , SM Engel , K Boggess , T Sturmer , AS Howe , MJ Funk

To read the full abstract: JAMA Pediatr 2019;173:160–168This paper describes a large population-based cohort of women in New Zealand who received metformin (n=1996 women) or insulin (n=1932) for treatment of gestational diabetes mellitus (GDM). There were no differences between the two groups in any measure of offspring childhood hei...
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ey0019.5-10 | Translational highlights | ESPEYB19

5.10. INZ-701 prevents ectopic tissue calcification and restores bone architecture and growth in ENPP1-deficient mice

Z Cheng , K O'Brien , J Howe , C Sullivan , D Schrier , A Lynch , S Jungles , Y Sabbagh , D Thompson

J Bone Miner Res. 2021 Aug;36(8):1594-1604.Abstract: https://pubmed-ncbi-nlm-nih-gov/33900645/In Brief: Enzyme replacement therapy with human ENPP1-Fc protein in Enpp1asj/asj mice, a murine model of ENPP1 deficiency, restored circulating levels of PPi, prevented clinical manifestations and decreased mortality.Commentary: ENPP1 deficiency causes gen...
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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