ESPE Yearbook of Paediatric Endocrinology

BMJ 2018;363:k5033. doi:10.1136/bmj.k5033Don’t skip this article!Lack of time, workload volume, the huge amounts of medical data.…. who has time to read all the information and medical literature?The authors introduce and discuss the pros and cons of using emoji in biomedical literature “allowing for vast swat...

Nature Digital Medicine 2018;1:39.DOI: 10.1038/s41746-018-0040-6Summary: This prospective observational study evaluated the performance of a diabetic retinopathy diagnostic system (IDx-DR) compared to the gold standard diagnostic for diabetic retinopathy. Nine hundred individuals with diabetes but without a history of diabetic retinopathy were examined. Re...

Diabetes Care. 2020;43(2):484–486. doi: 10.2337/dc19-1487.This retrospective study in Quebec, Canada included 3,544 adolescents and young adults with diabetes and 1 388 397 without diabetes. It concludes that between the ages of 15 and 25 years, the risks of psychiatric disorders and suicide attempts were substantially higher in adolescents and young adults with diabetes than those without ...

rakeshkgyl@gmail.com J Pediatr Hematol Oncol. 2022; 44: e469-e473. PMID: 34054040.Brief Summary: This monocentric, retrospective study investigated adrenal insufficiency (AI) prevalence in a large group of children with brain tumors (BT, 398 patients) and children treated with hematopoietic cell transplantation (HCT, 268 patients). AI was diagnosed in 14 BT patients (27.4% of the 51 tested) and 14 HCT re...

To read the full abstract: Elife 2019;8:e43999.Two populations of Kisspeptin neurons are described in the hypothalamus. One population is located in the rostral part of the hypothalamus (the anteroventral periventricular nucleus, AVPV); the other is in the arcuate nucleus (ARC). The major difference between these populations is the opposing effects of 17b-estradiol (E2) on Kiss1...

Lancet Public Health 2018;3:e419–e428.DOI 10.1016/S2468-2667(18)30135-XURL: http://www.ncbi.nlm.nih.gov/pubmed/30122560Summary: The long-term effects on health outcomes of dietary carbohydrate intake was investigated in a large prospective cohort of 15,428 US adults aged 45–64 years with 25 years foll...

In brief: This study investigated the effect of infigratinib, a selective and orally bioavailable FGFR1-3 inhibitor, administered at different doses or according to different dosing regimens, on bone growth in a mouse model mimicking achondroplasia (Fgfr3Y367C/+). This study was partially sponsored by a grant from BridgeBio/QED Therapeutics.Commentary: Achondroplasia is one of the most common constitutional bone diseases (> 300,000 affecte...

Diabetes Care. 2021 Apr 26:dc202308. doi: 10.2337/dc20-2308. PMID: 33905344.In brief: The multicenter SEARCH for Diabetes in Youth Study assessed cognitive function in adolescents and young adults with type 1 diabetes mellitus (T1DM) (n=1095) or T2DM (n=285). Mean age was 21.6±5.1 years and mean diabetes duration 11.0±3.4 years. Having T2DM was associated wit...

PLoS ONE 2021;16: e0245372. doi: 10.1371/journal.pone.0245372– According to pharmacopeia, unopened insulin vials must be stored in a refrigerator (2–8 °C) while storage at ambient temperature (25–28 °C) is usually permitted for the 4-week usage period during treatment– The authors investigated whether insulin remains stable and retains biological activity...

Nutrients. 2021 Oct 14;13(10):3590. PMID: 34684591Brief Summary: This multi-center, prospective, randomized, double-blind study reports the effects of two different oral nutritional supplements (ONS) on growth in ‘picky eaters’ children at risk of malnutrition in India. Anthropometric measures (weight, height, weight-for-height, body mass index (BMI), and mid-upper-arm circumference were evaluated at day 1, 30, 60 and 90. Both types of...