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14.11. Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition

M Fulde , F Sommer , B Chassaing , K van Vorst , A Dupont , M Hensel , M Basic , R Klopfleisch , P Rosenstiel , A Bleich , F Backhed , AT Gewirtz , MW Hornef

To read the full abstract: Nature 2018;560:489493.This paper reports competitive gut colonization experiments in mice. Compared to adult mice, neonatal mice showed much higher expression of the flagellin receptor Tlr5 in their intestinal epithelial cells, and exposure to this protein during the first 2 weeks of life, before weaning, was crucial in determining lifelong...

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ey0018.14-14 | (1) | ESPEYB18

14.14. The impact of sex on gene expression across human tissues

Oliva Meritxell , Munoz-Aguirre Manuel , Kim-Hellmuth Sarah , Wucher Valentin , Gewirtz Ariel DH , Cotter Daniel J , Parsana Princy , Kasela Silva , Balliu Brunilda , Vinuela Ana , Castel Stephane E , Mohammadi Pejman , Aguet Francois , Zou Yuxin , Khramtsova Ekaterina A , Skol Andrew D , Garrido-Martin Diego , Reverter Ferran , Brown Andrew , Evans Patrick , Gamazon Eric R , Payne Anthony , Bonazzola Rodrigo , Barbeira Alvaro N , Hamel Andrew R , Martinez-Perez Angel , Soria Jose Manuel , GTEx Consortium , Pierce Brandon L , Stephens Matthew , Eskin Eleazar , Dermitzakis Emmanouil T , Segre Ayellet V , Im Hae Kyung , Engelhardt Barbara E , Ardlie Kristin G , Montgomery Stephen B , Battle Alexis J , Lappalainen Tuuli , Guigo Roderic , Stranger Barbara E

Science 2020 Sep; 369(6509): eaba3066https://bit.ly/3wMzM8xBy integrating sex-specific Genotype-Tissue Expression (GTEx) data with gene function and transcription factor binding annotations, these authors describe mechanisms contributing to sex differences in the human transcriptome.Many complex human traits and diseases exhibit sex-specific characteristics. These sex differences have b...

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ESPE Yearbook of Paediatric Endocrinology

14.11. Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition

14.14. The impact of sex on gene expression across human tissues

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