ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0018.5-14 | Advances in skeletal biology | ESPEYB18

5.14. Piezo1 inactivation in chondrocytes impairs trabecular bone formation

Hendrickx Gretl , Fischer Verena , Liedert Astrid , von Kroge Simon , Haffner-Luntzer Melanie , Brylka Laura , Pawlus Eva , Schweizer Michaela , Yorgan Timur , Baranowsky Anke , Rolvien Tim , Neven Mona , Schumacher Udo , Beech David J , Amling Michael , Ignatius Anita , Schinke Thorsten

J Bone Miner Res. 2021 Feb;36(2):369–384 Abstract: https://pubmed.ncbi.nlm.nih.gov/33180356/In brief: Chondrocyte-specific ablation of the mechano-sensory Piezo1 results in substantially impaired formation of secondary spongiosa during endochondral bone formation. The study explores this unexpected finding and show that mechano-sensing in growth plate chondrocytes directly reg...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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