ISSN 1662-4009 (online)

ey0019.15-1 | Obesity | ESPEYB19

15.1. Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes

JP Frias , MJ Davies , J Rosenstock , FC Perez Manghi , L Fernandez Lando , BK Bergman , B Liu , X Cui , K Brown , SURPASS-2 Investigators

N Engl J Med. 2021;385(6):503-15. doi: 10.1056/NEJMoa2107519.PubMed ID: 34170647Brief summary: this randomized control trial in 1879 adults with type 2 diabetes compared effects of once-weekly Tirzepatide (5, 10 or 15 mg) versus once-weekly Semaglutide (1 mg) on glycemic control. After 40 weeks, all doses of Tirzepatide were superior to Semaglutide on lowering HbA1c.Gluca...

ey0021.11-2 | Interventions for Weight Loss: New Findings | ESPEYB21

11.2. Mutations in the leptin-melanocortin pathway and weight loss after bariatric surgery: a systematic review and meta-analysis

N Zhang , H Wang , S Ran , Z Wang , B Zhou , S Wang , Z Li , B Liu , Y Nie , Y Huang , H Meng

Brief Summary: This review evaluated the impact of gene mutations in the leptin-melanocortin pathway on short- and long-term outcomes after bariatric surgery, which is still the most effective treatment for severe obesity. This topic is of high clinical relevance, since such mutations play an important role in hunger regulation and energy homeostasis [1, 2] and may therefore confer weight regain after bariatric surgery [3]. To date there have been few publications, often with ...

ey0018.2-14 | Gestational Diabetes Mellitus: Neonatal and Long-term Consequences | ESPEYB18

2.14. Early diagnosed gestational diabetes mellitus is associated with adverse pregnancy outcomes: A prospective cohort study

B Liu , J Cai , Y Xu , Y Long , L Deng , S Lin , J Zhang , J Yang , L Zhong , Y Luo , Y Zhou , Y Zhang , Z Li , H Chen , Z Wang

J Clin Endocrinol Metab. 2020 Dec 1;105(12):dgaa633. doi: 10.1210/clinem/dgaa633. PMID: 32898218.In this study, low risk pregnant women had an ‘early’ OGTT at 18-20 weeks of gestation and these results were correlated with the standard OGTT at 24-28 weeks. Pregnant women with Gestational diabetes mellitus (GDM) who had early OGTT still had a higher risk of delivering macrosomic in...

ey0019.3-9 | New genes | ESPEYB19

3.9. Upregulation of GBP1 in thyroid primordium is required for developmental thyroid morphogenesis

RM Yang , M Zhan , QY Zhou , XP Ye , FY Wu , M Dong , F Sun , Y Fang , RJ Zhang , CR Zhang , L Yang , MM Guo , JX Zhang , J Liang , F Cheng , W Liu , B Han , Y Zhou , SX Zhao , HD Song

Genet Med. 2021 Oct;23(10):1944-1951. doi: 10.1038/s41436-021-01237-3. Epub 2021 Jun 30. PMID: 34194003Brief Summary: This genetic and developmental study identified pathogenic mutations in GBP1in patients with congenital hypothyroidism investigated by exome sequencing. In the zebrafish model, knockdown experiments revealed hypothyroidism and disordered thyroid morphology. These d...