ey0018.10-14 | (1) | ESPEYB18
S Sachs
, A Bastidas-Ponce
, S Tritschler
, M Bakhti
, A Bottcher
, MA Sanchez-Garrido
, M Tarquis-Medina
, M Kleinert
, K Fischer
, S Jall
, A Harger
, E Bader
, S Roscioni
, S Ussar
, A Feuchtinger
, B Yesildag
, A Neelakandhan
, CB Jensen
, M Cornu
, B Yang
, B Finan
, RD Di Marchi
, MH Tschop
, FJ Theis
, SM Hofmann
, TD Muller
, H Lickert
Nature Metabolism. 2020;2(2):192209. doi: 10.1038/s42255-020-0171-3.This experimental mouse study examined whether or not dedifferentiated β cells could be reversed or targeted by pharmacological intervention for diabetes remission. They identified evidence for β-cell dedifferentiation and dysfunction which could be reversed by single and combined pharmacological approach...