ISSN 1662-4009 (online)

ey0018.5-8 | Translational highlights | ESPEYB18

5.8. Hormonal regulation of biomineralization

Arnold Andrew , Dennison Elaine , Kovacs Christopher S , Mannstadt Michael , Rizzoli Rene , Brandi Maria Luisa , Clarke Bart , Thakker Rajesh V

Nat Rev Endocrinol. 2021 May;17(5):261–275 Abstract: https://pubmed.ncbi.nlm.nih.gov/33727709/In brief: This article systematically reviews the current advances in the understanding of mineral metabolism with focus on the regulation of mineralization in skeletal tissue and inhibition of mineralization in non-skeletal tissue. This is mandatory reading for any aspiring endocrino...

ey0016.10-19 | (1) | ESPEYB16

10.19. Diabetes relief in mice by glucose-sensing insulin-secreting human [alpha]-cells

Furuyama Kenichiro , Chera Simona , van Gurp Leon , Oropeza Daniel , Ghila Luiza , Damond Nicolas , Vethe Heidrun , Paulo Joao A , Joosten Antoinette M , Berney Thierry , Bosco Domenico , Dorrell Craig , Grompe Markus , Raeder Helge , Roep Bart O , Thorel Fabrizio , Herrera Pedro L

To read the full abstract: Nature 567, 43–48 (2019)Cell engineering might be a way to reinstall insulin-production in the pancreas of people with autoimmune diabetes. This experimental mouse study achieved to switch human alpha cells to secrete insulin.Cell-identity switches, in which terminally differentiated cells are converted into different cell types, rep...