ey0021.1-3 | New Mechanisms | ESPEYB21
M. Cheung L.Y.
, Menage L.
, Rizzoti K.
, Hamilton G.
, Dumontet T.
, Basham K.
Brief Summary:This study used single-cell RNA-seq and murine transgenic models combined with elegant cell lineage tracing to characterise the gene expression profiles and trajectories of pituitary thyrotropes. It identifies a novel population of pituitary thyrotropes that co-express Nr5a1 (Sf1) and Pouf1 (Pit1) and a novel developmental trajectory for a subpopulation of Nr5a1-derived thyrotropes.Classical studies on pituitary cell lineages and cell diffe...