ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0018.15-16 | (1) | ESPEYB18

15.16. The effects of 20-kDa human placental GH in male and female GH-deficient mice: an improved human GH?

List Edward O , Berryman Darlene E , Basu Reetobrata , Buchman Mathew , Funk Kevin , Kulkarni Prateek , Duran-Ortiz Silvana , Qian Yanrong , Jensen Elizabeth A , Young Jonathan A , Yildirim Gozde , Yakar Shoshana , Kopchick John J

Endocrinology 2020 Aug 1;161(8):bqaa097.https://bit.ly/3zqg6c5This study, in a GH-deficient mouse model, shows that a 20-kDa variant of placental GH (20k-GH-V) retains the growth-promoting effects of normal pituitary-derived GH (GH-N), but with the advantages of having no diabetogenic or prolactin receptor (PRLR)-mediated tumour-promoting effects.One of the first described actions of GH...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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