ey0021.3-3 | Hypothalamus-Pituitary-Axis Regulation | ESPEYB21
Guillou Anne
, Kemkem Yasmine
, Lafont Chrystel
, Fontanaud Pierre
, Calebiro Davide
, Campos Pauline
, Bonnefont Xavier
, Fiordelisio-Coll Tatiana
, Wang Ying
, Brule Emilie
, Bernard Daniel J
, Tissier Paul Le
, Steyn Frederik
, Mollard Patrice
Brief Summary: This study examined the pulsatile secretion of TSH and its regulatory role in thyroid hormone (TH) synthesis in mice. Using a novel ultra-sensitive ELISA for mouse TSH, it shows that TSH pulsatility plays a critical role in regulating thyroid function.In addition to mapping the normal TSH secretion pattern in healthy mice, and the secretion pattern in a mouse model of disease (mouse made hypothyroid by an iodine-deficient diet enriched wit...