ESPE Yearbook of Paediatric Endocrinology

J Endocrinol. 2020 May;245(2):315–326. doi: 10.1530/JOE-20-0012. PMID: 32171178.As it is not possible to study the histology of the pancreas post-partum in humans, this study used a mouse model of mild glucose intolerance to assess the changes in pancreatic islets after post-partum and assess the impact of pro-inflammatory cytokines. Mice with glucose intolerance during pregnancy continue...

Psychoneuroendocrinology. 2022; 137: 105604. PMID: 34971856https://pubmed.ncbi.nlm.nih.gov/34971856/Brief Summary: This study evaluated the associations between the amygdala total and sub-region volumes in relation to sex hormones – estradiol and free testosterone – as a function of age and genetic differences in androgen receptor sensitivity in 297 adolescents. It provides new kno...

To read the full abstract: The FASEB Journal 2019;33:12680–12695.These authors conditionally deleted the IGF1 receptor gene (IGF1R) in tenocytes using a tamoxifen-inducible Cre-recombinase system and then stimulated plantaris tendon growth in adult mice via mechanical loading. Mice that lacked IGF1R in their tenocytes showed reduced cell proliferation and tendon growth in response to mechanical loading. These studies indicate that IGF1 sign...

To read the full abstract: Diabetes Care. 2017;40:849-855Coping strategies for people with chronic diseases include working on risk factors as well as using and employing resilience factors in daily coping strategies. Both strengthes and difficulties may be experienced by people with T1DM. In this study, strengths were strongly related to key resilient outcomes, even in the presence of well-documente...

To read the full abstract: Pediatr Diabetes. 2018 19(5):1007-1013Severe hypoglycemia is one of the most threatening events in management of diabetes for parents and relatives. Although parents and patients are taught about the management in the acute situation, many are unable to use injectable glucagon. For moderate hypoglycemia, injectable glucagon seems to be no alternative for most caregivers. N...

Int J Mol Sci. 2020 Nov 9;21(21):8403. doi: 10.3390/ijms21218403. PMID: 33182400This case report describes a patient with clinically diagnosed partial androgen insensitivity syndrome (PAIS). However, no mutation in the androgen receptor gene was identified. Instead, whole genome sequencing revealed a heterozygous point mutation inherited from the mother in the FKBP4 gene. This gene i...

moab@chop.edu Pediatr Blood Cancer. 2022; 69: e29674. PMID: 35338690.Brief Summary: Childhood cancer survivors (CCS), particularly those exposed to local irradiation, are at increased risk for thyroid disease and thyroid surgery. This retrospective, monocentric study compared rates of surgical complications among 42 CCS undergoing thyroid surgery compared to 596 non-CCS controls (sporadic/familial thyroid cance...

To read the full abstract: N Engl J Med. 2020;382(6):525–533.In brief: High dose vitamin D supplementation of 4400 IU compared with 400 IU during the prenatal period alone to mothers of offspring at risk for asthma did not influence the incidence of asthma and recurrent wheeze in children aged 6-years.Commentary: Vitamin D deficiency has been im...

To read the full abstract: Pediatr Diabetes. 2020 Mar;21(2):377–383. doi: 10.1111/pedi.12956. PMID: 31808586Across all age groups, management of type 1 diabetes (T1DM) places substantial workload, responsibility and emotional burden, such as worries and stress, on families. This study explored parent perceptions of the burdens of caring for very young children with T1DM. Semi-structured qu...

To read the full abstract: Diabetes Care. 2017;40:1002-1009Quality of life (QOL) measures have increasingly been considered as end-points of medical interventions. Both general QOL and health- and disease-specific quality of life can be assessed using well defined and validated questionnaires. The TEENs study is an international, cross-sectional study of youth with T1DM. 5,887 participants were follo...