ESPE Yearbook of Paediatric Endocrinology

Brief Summary:This review summarizes findings in mice on a new lineage of osteoclast-related cells that play a role in bone homeostasis at the resorption front. These ‘osteomorphs’ derive from fission of osteoclasts and are long-lived. They seem to interact with RANKL and may be involved in the rebound bone loss that is seen following denosumab (RANKL antagonist) therapy. The authors speculate on translational roles for osteomorphs in humans, including bone catabolic...