ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0021.1-8 | Novel Genes | ESPEYB21

1.8. The evolutionary conserved miR-137/325 tandem mediates obesity-induced hypogonadism and metabolic comorbidities by repressing hypothalamic kisspeptin

MS Avendano , C Perdices-Lopez , Y Guerrero-Ruiz , F Ruiz-Pino , AB Rodriguez-Sanchez , MJ Sanchez-Tapia , V Sobrino , R Pineda , A Barroso , A Correa-Saez , M Lara-Chica , JC Fernandez-Garcia , AB Garcia-Redondo , R Hernanz , M Ruiz-Cruz , D Garcia-Galiano , N Pitteloud , MA Calzado , AM Briones , MJ Vazquez , M Tena-Sempere

Brief Summary: This study provides evidence for the role of miR-137/325 in obesity-induced hypogonadism (OIH) and metabolic dysfunction.Obesity is associated with different forms of gonadal and reproductive dysfunction, including central male hypogonadism (1, 2). Although weight loss is the ideal therapeutic strategy for patients with OIH, significant weight loss is usually difficult to achieve only with lifestyle changes. Hence, androgen administration ...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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