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7.2. SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

MJ Vazquez , CA Toro , JM Castellano , F Ruiz-Pino , J Roa , D Beiroa , V Heras , I Velasco , C Dieguez , L Pinilla , F Gaytan , R Nogueiras , MA Bosch , OK Ronnekleiv , A Lomniczi , SR Ojeda , M Tena-Sempere

To read the full abstract: Nat Commun. 2018 Oct 10;9(1):4194.This study identifies Sirtuin 1 (SIRT1), a fuel-sensing deacetylase, as a molecule that restrains female puberty via epigenetic repression of the puberty-activating gene, Kiss1 in rats.The last few years have brought evidence regarding the epigenetic control of the onset of puberty. It is now cle...

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ey0018.7-10 | Basic Science | ESPEYB18

7.10. Central ceramide signaling mediates obesity-induced precocious Puberty

V Heras , JM Castellano , D Fernandois , I Velasco , E Rodriguez-Vazquez , J Roa , MJ Vazquez , F Ruiz-Pino , M Rubio , R Pineda , E Torres , MS Avendano , A Paredes , L Pinilla , D Belsham , C Dieguez , F Gaytan , N Casals , M Lopez , M Tena-Sempere

Cell Metab. 2020 Dec 1;32(6):951966.e8. 10.1016/j.cmet.2020.10.001. PMID: 33080217. https://www.sciencedirect.com/science/article/pii/S1550413120305349?via%3DihubIn brief: This study reveals the critical role of hypothalamic ceramide synthesis in the induction of precocious puberty in obe...

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ey0016.7-3 | Basic Science | ESPEYB16

7.3. Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling

J Roa , A Barroso , F Ruiz-Pino , MJ Vazquez , P Seoane-Collazo , N Martinez-Sanchez , D Garcia-Galiano , T Ilhan , R Pineda , S Leon , M Manfredi-Lozano , V Heras , M Poutanen , JM Castellano , F Gaytan , C Dieguez , L Pinilla , M Lopez , M Tena-Sempere

To read the full abstract: Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10758E10767.The authors show for the first time that central AMP-activated protein kinase (AMPK), the major cellular energy sensor, interplays with Kiss1 to control puberty onset.AMPK is an indispensable cellular energy sensor (1). Beside its ability to directly sense ener...

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ESPE Yearbook of Paediatric Endocrinology

7.2. SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

7.10. Central ceramide signaling mediates obesity-induced precocious Puberty

7.3. Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling

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