ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0015.12-14 | Important for clinical practice (1) | ESPEYB15

12.14 Cognitive Function in a Randomized Trial of Evolocumab

RP Giugliano , F Mach , K Zavitz , C Kurtz , K Im , E Kanevsky , J Schneider , H Wang , A Keech , TR Pedersen , MS Sabatine , PS Sever , JG Robinson , N Honarpour , SM Wasserman , BR Ott , EBBINGHAUS Investigators

To read the full abstract: N Engl J Med 2017;377:633-643Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates levels of plasma LDL-C by interacting with the LDL receptor. After binding and internalization, PCSK9 directs the LDL receptor to lysosomal degradation and inhibits its recycling to the cell surface, and thus accelerates the degradation of hepatic LDL receptors. This reduces the ...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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