ISSN 1662-4009 (online)

ey0018.9-13 | Cardiometabolic risk in chronic disease | ESPEYB18

9.13. Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia

S Morel , P Leveille , M Samoilenko , A Franco , J England , N Malaquin , V Tu , GB Cardin , S Drouin , F Rodier , S Lippe , M Krajinovic , C Laverdiere , D Sinnett , G Lefebvre , E Levy , V Marcil

Sci Rep. 2020 Dec 9; 10: 21507. https://pubmed.ncbi.nlm.nih.gov/33299020/This cross-sectional study of 246 childhood acute lymphoblastic leukemia (cALL) survivors aimed to analyze the relationships between various blood biomarkers and cardiovascular risk, and to test the link between endotoxemia and cardiometabolic complications. A high leptin-adiponectin ratio was associated with obesity, ...

ey0021.9-16 | Bone Health and Chronic Diseases | ESPEYB21

9.16. Vertebral body reshaping after fractures: an important index of recovery in glucocorticoid-treated children

J Ma , K Siminoski , JL Jaremko , K Koujok , MA Matzinger , N Shenouda , N Wilson , M Cheng , N Alos , S Atkinson , EA Cummings , J Ho , C Rodd , AM Sbrocchi , R Stein , R Barr , E Cairney , DB Dix , CV Fernandez , R Grant , J Halton , S Israels , C Laverdiere , VA Lewis , DA Cabral , A Huber , K Houghton , R Jurencak , B Lang , M Larche , CMA LeBlanc , P Miettunen , J Roth , R Scuccimarri , L Bell , T Blydt-Hansen , G Filler , J Feber , V Phan , K Smit , F Rauch , LM Ward

Brief Summary: This prospective natural history study examined the timing and positive indicators for reshaping of vertebral fractures (VF) in glucocorticoid (GC)-treated patients with chronic diseases. Complete VF reshaping occurred in 82.3% of patients, with similar frequencies in all diagnosis groups (leukemia, rheumatic disorders and nephrotic syndrome) in a median time of 1.3 years. Likelihood of VF reshaping was positively related to higher lumbar spine bone mineral dens...