ESPE Yearbook of Paediatric Endocrinology

grahamo@diabetesnsw.com.au Diabetes Res Clin Pract 2022, 183:109083. doi: 10.1016/j.diabres.2021.109083Brief Summary: The incidence of Type 1 diabetes (T1D) in children and adolescents is increasing in many nations. The 10th edition of the International Diabetes Federation Atlas reports that an estimated 108,300 youth aged < 15 years a...

Pediatr Diabetes. 2018 May 15. doi: 10.1111/pedi.12691There is a small but significant debate as to whether or not type 1 (T1D) and type 2 diabetes (T2D) are the same disease with albeit different course. It might therefore be prudent to include into a chapter on T1D a publication on T2D. This study aimed to describe recent medication patterns and changes in medication patterns and glycemic con...

Diabetes Care. 2021 Apr 26:dc202308. doi: 10.2337/dc20-2308. PMID: 33905344.In brief: The multicenter SEARCH for Diabetes in Youth Study assessed cognitive function in adolescents and young adults with type 1 diabetes mellitus (T1DM) (n=1095) or T2DM (n=285). Mean age was 21.6±5.1 years and mean diabetes duration 11.0±3.4 years. Having T2DM was associated wit...

JAMA. 2021;326(8):717-27. doi: 10.1001/jama.2021.11165.PubMed ID: 34427600Brief summary: This large repeated cross-sectional study identified all individuals aged <20 years with physician-diagnosed diabetes in 6 areas in the US in 2001, 2009, and 2017. Over these 16 years, the prevalence of Type 1 diabetes (T1D) increased by 45% (95% CI, 40%–50%) and the prevalence of Type 2 diabetes...

Brief summary: Using data collected from 1608 adolescents and young adults (aged 10–24.9 years) with type 1 or type 2 diabetes recruited in the SEARCH for Diabetes in Youth study, this study assessed the cross-sectional association between diabetes stigma and diabetes outcomes. Diabetes stigma was more common among females and was associated with suboptimal glycemic outcomes and acute and chronic complications.Stigma, defined as a negative social ju...

Brief summary: The incidences of T1D and T2D in children and young people increased in the USA over the last 2 decades. For the first time, the incidence of T2D has surpassed that of T1D.Comment: The SEARCH study has served as a national resource to explore the epidemiology and consequences of diabetes in the US. Published over the years, the findings contribute to understanding future trends in other parts of the world. Overall, the current report shows...

Brief Summary: Rare forms of diabetes (‘monogenic diabetes’) are caused by a single rare gene variant, while adult-onset T2D is influenced by thousands of common genetic variants. This study reveals that youth-onset T2D shares some genetic features with both monogenic and typical adult-onset T2D, marked by both common and rare genetic variantsComment: A significant challenge is understanding why the course of T2D in children and teenagers is mo...