ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

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ey0018.6-13 | Basic Research in Gender Dysphoria | ESPEYB18

6.13. Behavioral and neurobiological effects of GnRH agonist treatment in mice - potential implications for puberty suppression in transgender individuals

C Anacker , E Sydnor , BK Chen , CC LaGamma , JC McGowan , A Mastrodonato , HC Hunsberger , R Shores , RS Dixon , BS McEwen , W Byne , HFL Meyer-Bahlburg , W Bockting , AA Ehrhardt , CA Denny

Neuropsychopharmacology. 2021 Apr;46(5):882–890.doi: 10.1038/s41386-020-00826-1. PMID: 32919399.This mouse study addresses the question of the psychological effects of treatment with the GnRH analogue (GnRHa) leuprolide. Six-week-old, i.e. early-pubertal, male and female mice were injected daily with leuprolide (20 μg) or saline for 6 weeks. The mice were subjected to a number...
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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