ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

Page 1 of about 5 results

ey0015.7-2 | Review: Epigenetic control of female puberty | ESPEYB15

7.2 Hypothalamic Epigenetics Driving Female Puberty

CA Toro , CF Aylwin , A Lomniczi

To read the full abstract: J Neuroendocrinol. 2018; 30(7): e12589Classically, the re-awakening of the GnRH system around puberty is considered to be under the control of a variety of genes that work in coordinated networks operating in the hypothalamus1. Very recent evidence suggests that a dual mechanism of epigenetic regulation affecting the transcriptional activity of neurons involved i...
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ey0015.7-1 | New concept: Epigenetic control of puberty | ESPEYB15

7.1 Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty

CA Toro , H Wright , CF Aylwin , SR Ojeda , A Lomniczi

To read the full abstract: Nat Commun. 2018 Jan 4;9(1):57The hypothalamic-pituitary-gonadal axis controls the onset of puberty and the acquisition of the reproductive function. A subset of neurons in the anterior hypothalamus secretes gonadotropin-releasing hormone (GnRH) which, through its pattern of release controls all aspects of reproduction throughout life. The secretory activity of GnR...
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ey0018.7-11 | Basic Science | ESPEYB18

7.11. MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons

AP Abreu , CA Toro , YB Song , VM Navarro , MA Bosch , A Eren , JN Liang , RS Carroll , AC Latronico , OK Ronnekleiv , CF Aylwin , A Lomniczi , S Ojeda , UB Kaiser

J Clin Invest. 2020 Aug 3;130(8):4486–4500. 10.1172/JCI136564. PMID: 32407292 https://www.jci.org/articles/view/136564In brief: This study in rats and non-human primate models investigated the mechanisms by which MKRN3 regulates pubertal onset in rats and non-human primates.Comment: Pubertal timing is in...
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ey0019.7-9 | Basic Science | ESPEYB19

7.9. Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2

S Leon , R Talbi , EA McCarthy , K Ferrari , C Fergani , L Naule , JH Choi , RS Carroll , UB Kaiser , CF Aylwin , A Lomniczi , VM Navarro

Elife. 2021 Sep 8;10:e69765. doi: 10.7554/eLife.69765. PMID: 34494548. https://elifesciences.org/articles/69765Brief Summary: Using a database for arcuate nucleus transcripts, this study identifies Nhlhl2 as a key regulator of the Kiss1 gene in male mice.The timing of puberty onset is i...
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ey0019.7-13 | Basic Science | ESPEYB19

7.13. Multi- and transgenerational outcomes of an exposure to a mixture of endocrine-disrupting chemicals (EDCs) on puberty and maternal behavior in the female rat

D Lopez-Rodriguez , CF Aylwin , V Delli , E Sevrin , M Campanile , M Martin , D Franssen , A Gerard , S Blacher , E Tirelli , A Noel , A Lomniczi , AS Parent

Environ Health Perspect.2021 Aug;129(8):87003. doi: 10.1289/EHP8795. Epub 2021 Aug 12. PMID: 34383603. https://ehp.niehs.nih.gov/doi/10.1289/EHP8795?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedBrief Summary: Using a rode...
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ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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