ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Stem Cells, 2020;38(6):769–781.In brief: A novel population of osteoprogenitor cells in proximity to transcortical channels is found to persist during skeletal maturation. These migrate, expand and contribute to bone formation.Commentary: Bone formation and regeneration requires multiple distinct populations of progeni...

To read the full abstract: Development 2017; 144:3533-3546Endochondral ossification is the process by which the embryonic cartilaginous scaffold of most bones is gradually replaced by bone. During this process chondrocytes proliferate, undergo hypertrophy and maturation and form the growth plate, essential for bone growth. Postnatal bone growth is tightly regulated by both systemic and lo...

To read the full abstract: Cell. 2018 Dec 13;175(7):1756–1768.e17.Irisin, a cytokine secreted by muscle during exercise, effects bone resorption and the differentiation of preadipocytes into thermogenic brown fat cells by displacing tethers between the cell and extracellular matrix molecules. Physical activity can reverse age-dependent decline in skeletal muscle, preventing osteopor...