ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: J Clin Endocrinol Metab. 2019;104:5540–5546.This single center, retrospective study analyzed the prevalence and natural history of amiodarone associated thyroid disease in 190 children and young adults with detailed thyroid function tests. Amiodarone induced hypothyroidism (AIH) and thyrotoxicosis (AIT) are well known entities due to direct thyroid toxicity. Further, subclinical hypothyroidism (SCH) is caused by a...

Brief Summary: Countries differ in their approaches to newborn screening (NBS) for congenital adrenal hyperplasia (CAH), a group of genetic disorders affecting adrenal steroidogenesis. This survey describes the protocols, approaches, and outcomes of CAH screening across different countries.Members of the International Society for Neonatal Screening were invited to complete a questionnaire in 2021. Members representing 23 screening programs from Europe, S...

To read the full abstract: Pediatrics. 2018;142(4). pii: e20181199.This unique study investigated the incidence of congenital hypothyroidism from the start of the newborn screening in 1979 to 2016. The authors report a marked increase in incidence from 0.27 cases per 1000 live births in 1979–1991 to 0.41 in 1992–2004 and 0.65 in 2005–2016.A major str...

Brief Summary: This single-center, retrospective cohort study compared the final adult height (FAH) of 92 male childhood cancer survivors (CCS) with growth hormone deficiency GHD) treated with growth hormone alone (monotherapy) or in combination with an aromatase inhibitor. The addition of AI to GH therapy did not improve FAH.This study from the Children’s Hospital of Philadelphia is the most extensive study on the role of AI associated with GH in i...

Diabetes Care. 2021 Nov;44(11):2582-2585. doi: 10.2337/dc21-0416. PMID: 34518377.Brief Summary: This pilot study, in patients with post-pancreatectomy diabetes due to congenital hyperinsulinism, assessed pump-delivered insulin and glucagon (Bihormonal Bionic Pancreas, BHBP) to regulate blood glucose levels. BHBP controlled post-prandial glucose levels better than a conventional insulin pump but fur...