ISSN 1662-4009 (online)

ey0021.10-8 | New Genetic Insights | ESPEYB21

10.8. Familial aggregation and heritability of childhood-onset and adult-onset type 1 diabetes: a Swedish register-based cohort study

Y Wei , S Liu , T Andersson , M Feychting , R Kuja-Halkola , S Carlsson

Brief Summary: This register-based cohort study compared the familial aggregation and heritability of childhood-onset (≤18 years) vs. adult-onset (19-30 years) type 1 diabetes (T1D), using data collected from over 2.9 million individuals born in Sweden between 1982-2010, and from their relatives. Adult-onset T1D showed weaker familial aggregation and lower heritability than childhood-onset T1D.Although T1D is considered a typical childhood...