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ey0018.5-9 | Translational highlights | ESPEYB18

5.9. Articular cartilage regeneration by activated skeletal stem cells

Murphy Matthew P , Koepke Lauren S , Lopez Michael T , Tong Xinming , Ambrosi Thomas H , Gulati Gunsagar S , Marecic Owen , Wang Yuting , Ransom Ryan C , Hoover Malachia Y , Steininger Holly , Zhao Liming , Walkiewicz Marcin P , Quarto Natalina , Levi Benjamin , Wan Derrick C , Weissman Irving L , Goodman Stuart B , Yang Fan , Longaker Michael T , Chan Charles K F

Nat Med. 2020 Oct;26(10):15831592 Abstract: https://pubmed.ncbi.nlm.nih.gov/32807933/In brief: Improved treatments for osteoarthritis and other degenerative joint diseases are urgently needed. This study demonstrates, for the first time, that the synovial microenvironment can be modified to allow resident skeletal stem cells to form hyaline articular cartilage and thereby reg...

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ey0021.14-17 | YES contributions by Dr. Simge Eren (14.17 and 14.18) | ESPEYB21

14.17. A maternal brain hormone that builds bone

Babey Muriel E. , Krause William C. , Chen Kun , Herber Candice B. , Torok Zsofia , Nikkanen Joni , Rodriguez Ruben , Zhang Xiao , Castro-Navarro Fernanda , Wang Yuting , Wheeler Erika E. , Villeda Saul , Leach J. Kent , Lane Nancy E. , Scheller Erica L. , Chan Charles K. F. , Ambrosi Thomas H. , Ingraham Holly A.

Brief Summary:This study shows that brain-derived cellular communication network factor 3 (CCN3) is a potent osteoanabolic hormone to enhance bone formation in lactating female mice. CCN3 is produced by KISS1 neurons in the brain, and operates through a unique signaling pathway that interacts with bone-forming osteoblasts leading to increased bone formation.During lactation, the increased calcium demand for milk production leads to considerable bone loss...

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ESPE Yearbook of Paediatric Endocrinology

5.9. Articular cartilage regeneration by activated skeletal stem cells

14.17. A maternal brain hormone that builds bone

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