ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0018.14-10 | (1) | ESPEYB18

14.10. Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

Choi Sekyu , Zhang Bing , Ma Sai , Gonzalez-Celeiro Meryem , Stein Daniel , Jin Xin , Kim Seung Tea , Kang Yuan-Lin , Besnard Antoine , Rezza Amelie , Grisanti Laura , Buenrostro Jason D , Rendl Michael , Nahrendorf Matthias , Sahay Amar , Hsu Ya-Chieh

Nature 2021; 592: 428–432https://www.nature.com/articles/s41586-021-03417-2These authors report that in mice the stress hormone corticosterone (the rodent equivalent of cortisol in humans) acts on dermal papillae to suppress expression of Gas6 (encoding growth arrest specific 6) and thereby cause hair follicle stem cell (HFSC) quiescence and reduced hair growth. They show that...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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