ESPE Yearbook of Paediatric Endocrinology

Nat Rev Endocrinol 2021;17(8):484-95. doi: 10.1038/s41574-021-00507-zBrief Summary: This article reviews the results of clinical trials for modulators of glucagon-like peptide-1 (GLP1) activity, insulin-sensitizing thiazolidinediones, and inhibitors of the sodium-glucose cotransporter 2 (SGLT2) for the treatment of NAFLD and type 2 diabetes mellitus.Comment: NAFLD ha...

J Child Psychol Psychiatry. 2018 Dec;59(12):1228–1243.doi: 10.1111/jcpp.12833. PubMed ID: 29071722This comprehensive review summarizes the current knowledge on epidemiology, concomitant psychiatric diagnoses, behavioral characteristics and developmental trajectories of gender identity issues. It also reviews determinants of gender identity and expression, and the opt...

To read the full abstract: Pediatr Nephrol. 2017;32:949-964This is a comprehensive review on growth and sexual maturation during puberty in children with chronic kidney disease (CKD). Despite attention to preserve growth potential during pre-puberty and the availability of recombinant human growth hormone (rhGH), the achievement of normal pubertal height gain remains a challenge in CKD. In pr...

Brief Summary: This open-label, randomised phase 3 trial investigated the efficacy and safety of subcutaneous infusions of Dasiglucagon1, a glucagon analogue, as an add-on to standard of care (SoC) treatment in infants and children with congenital hyperinsulinism (CHI).Patients had documented CHI aged 0.6 to 10.9y, who had ≥3 episodes of hypoglycemia/week, defined as self-measured plasma glucose (SMPG) <3.9 mmol/L. Part 1 (weeks 1-4)...

Pediatrics. 2020 Sep;146(3):e20200265. doi: 10.1542/peds.2020-0265. PMID: 32778539.In brief: This cross-sectional analysis of a nationally representative US sample showed that 25.5% of US children and adolescents (10.6 million in 2016) are eligible for screening for diabetes according to American Diabetes Association (ADA) criteria. The eligibility criteria showed l...

TOPMed Anthropometry Working Group; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium et al. Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.Nat Genet. 2022 Mar;54(3):263-273.Abstract: https://pubmed-ncbi-nlm-nih-gov.proxy.kib.ki.se/35256806/In brief: Genome-wide association studies (GWAS) on unrelated individuals rely...

Diabetes Care 2018;41:1125–1131. DOI: 10.2337/dc18-er09a)• Many people currently in need of insulin are unable to access it.• Unaffordable price of insulin is a major barrier.• These authors analyse the causes of unsatisfactory access to insulin from a U.S. and global perspective.This article identifies the various ...

To read the full abstract: Nat Commun 2017;8:443G-protein-coupled receptors (GPCRs) are a large family of receptors localized at the cell membrane, detecting specific ligands such as hormones, neurotransmitters, odors, pheromones. Further, GCPRs are the main element for the photoisomerization process, necessary to convert a photon impulse to an electrical signal in photosensitive gan...

To read the full abstract: J Endocr Soc. 2019 Feb 7;3(4):699–713.This paper describes a retrospective study of patients with congenital hyperinsulinism (CHI) who were treated with mammalian target of rapamycin (mTOR) inhibitor, sirolimus, in a tertiary service, and reviews the 15 publications reporting CHI patients treated with sirolimus.The diffuse forms of C...

To read the full abstract: Annals of Global Health. 2020; 86(1): 43, 1–8. doi: https://doi.org/10.5334/aogh.2669• The authors assessed the prevalence of diabetic microvascular complications in 155 children and adolescents with Type 1 diabetes in northwestern Tanzania.• They observed poor diabetes control in 69% of the patients and a high rate of diabetic nephropathy (32.9%), retin...