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ey0020.10-5 | New Drugs for Children with T2DM | ESPEYB20

10.5. Once-weekly exenatide in youth with type 2 diabetes

WV Tamborlane , R Bishai , D Geller , N Shehadeh , D Al-Abdulrazzaq , EM Vazquez , E Karoly , T Troja , O Doehring , D Carter , J Monyak , CD Sjostrom

Brief summary: This study examined glycemic control following treatment with once-weekly exenatide 2 mg (Bydureon, AstraZeneca) in youth with T2D which was not optimally controlled. At 24 weeks, exenatide was superior to placebo in lowering HbA1c (least squares mean change, −0.36% with exenatide vs. +0.49% with placebo), with a between-group difference of −0.85%.Comment: The story of the development of exenatide is fascinating. It starts with...

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ey0019.7-8 | Basic Science | ESPEYB19

7.8. GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation

G Pellegrino , M Martin , C Allet , T Lhomme , S Geller , D Franssen , V Mansuy , M Manfredi-Lozano , A Coutteau-Robles , V Delli , S Rasika , D Mazur , A Loyens , M Tena-Sempere , J Siepmann , FP Pralong , P Ciofi , G Corfas , AS Parent , SR Ojeda , A Sharif , V Prevot

Nat Neurosci. 2021 Dec;24(12):1660-1672. doi: 10.1038/s41593-021-00960-z. Epub 2021 Nov 18. PMID: 34795451. https://www.nature.com/articles/s41593-021-00960-zBrief Summary: This neuroanatomical and physiological study in mice demonstrates that GnRH neurons attract glial cells in their vicinity via cellcell communication...

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ESPE Yearbook of Paediatric Endocrinology

10.5. Once-weekly exenatide in youth with type 2 diabetes

7.8. GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation

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