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ey0019.2-18 | Gestational Diabetes Mellitus: Neonatal and Long-term Consequences | ESPEYB19

2.18. Novel epigenetic link between gestational diabetes mellitus and macrosomia

BT Joyce , H Liu , L Wang , J Wang , Y Zheng , D Nannini , A Drong , S Shiau , W Li , J Leng , Y Shen , R Gao , A Baccarelli , G Hu , L Hou

Epigenomics. 2021 Aug;13(15):1221-1230. doi: 10.2217/epi-2021-0096. PMID: 34337972.Brief Summary: This case cohort study assessed whether epigenetic factors explain the link between gestational diabetes mellitus (GDM) and macrosomia. Epigenetic changes in the MEST gene were associated with both GDM and macrosomia.GDM leads to neonatal macrosomia and in the long-t...

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ey0015.12-8 | New Mechanism (1) | ESPEYB15

12.8 Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

CA Thaiss , M Levy , I Grosheva , D Zheng , E Soffer , E Blacher , S Braverman , AC Tengeler , O Barak , M Elazar , R Ben-Zeev , D Lehavi-Regev , MN Katz , M Pevsner-Fischer , A Gertler , Z Halpern , A Harmelin , S Aamar , P Serradas , A Grosfeld , H Shapiro , B Geiger , E Elinav

To read the full abstract: Science 2018;359:1376-1383The metabolic syndrome (MetS) is associated with dysfunctions of the intestinal barrier, leading to increased permeability and translocation of microbial molecules into the intestinal lamina propria and to circulation. The entry of pathogens through an impaired barrier leads to an increased risk of infection, as well as to chronic inflammation...

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ESPE Yearbook of Paediatric Endocrinology

2.18. Novel epigenetic link between gestational diabetes mellitus and macrosomia

12.8 Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

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