ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Horm Res Paediatr. 2018;90(1):1–7.The authors discuss why GnRH analog therapies should not be used in all girls with central precocious puberty (CPP), but only in those cases where the predicted benefits outweigh the risks and high cost of the treatment.Epidemiological studies in Europe and USA show declining average a...

To read the full abstract: Pregnancy Hypertens. 2019 Jan;15:134–140.This observational cohort study highlights the negative association between age at menarche and blood pressure in pregnancy, and the probable relationship with BMI and insulin resistance.Age at menarche (AAM) is influenced by genetic and environmental determinants (1). Given that some...

To read the full abstract: Arch Dis Child Fetal Neonatal Ed. 2019 Jul;104(4):F353–F359. PMID:30232094.In preterm and in the very low birthweight infants, hyperglycaemia is associated with increased risks of mortality, brain injury, retinopathy of prematurity and worse neurodevelopmental outcomes (1). Treatment of hyperglycaemia with continuous insulin infusion leads to increas...

To read the full abstract: Science 2017;358:1019-1027The gene-editing system CRISPR-Cas9 continues to surge through molecular biology labs and article titles. This article provides a new lab shelf, manipulating RNA, not DNA. This RNA editor could be used to treat conditions that are short term in nature, such as local inflammation. The RNA tool focuses on single-l...

Eur J Endocrinol. 2020;183:637–645. doi: 10.1530/EJE-20-0617.This study provides for the first time clear evidence that the block and replace (BR) strategy (combination of carbimazole plus levothyroxine) is not superior to the carbimazole dose titration (DT) strategy for treatment of paediatric Graves’ disease.Wood et al. present the first randomized c...

To read the full abstract: Front. Endocrinol. 2020 11:142. doi: 10.3389/fendo.2020.00142• A delayed transition from the infancy to the childhood growth stage contributes to sub-optimal growth outcomes.• Using a novel method to assess the timing of infancy-childhood transition (quantification of patterns of adjacent monthly weight-for-age z-score (WAZ) deviation correlations), th...

J Clin Endocrinol Metab, 2021. 106(11): p. 3184-3195. PMID: 34272849Brief Summary: This randomized, open-label, controlled, phase 3 trial compared the effects of once-weekly long-acting GH lonapegsomatropin versus daily GH in GHD children over a period of 52 weeks. Efficacy was evaluated by height velocity (HV) and height gain from baseline to end. The long-acting formulation showed not only non-inferiority but also superior efficacy compared to...

Diabetes. 2022;71:1591-1596. https://pubmed.ncbi.nlm.nih.gov/35499624/Brief Summary: This cross-sectional study compared trends in plasma C-peptide decline in 4,076 young people with type 1 diabetes (T1D), with trends in beta-cell loss in 235 pancreas donors. As expected, C-peptide declined over time, and this was particularly marked in children with T1D younger than 7 years. Of interest, p...

To read the full abstract: Obes Rev. 2019 Nov;20(11):1523–1541. doi: 10.1111/obr.12923.This is a thoughtful position statement by a number of leading obesity researchers and statisticians. They draw attention to 10 errors that are common in the scientific literature: 1. Using self-reported outcomes and ‘teaching to the test’ (achieving better scores simply by repeat testing); 2. L...

To read the full abstract: Nat Commun. 2018 19;9:2394.“Somatopause” causes the physiological decline over time in GH secretion leading to low IGF-I levels in aging subjects. GH has been proposed as an anti-aging therapy, but with no evidence of beneficial effects and with some potential risks [1,2]. Therefore, current guidelines do not recommend GH therapy as anti-aging treatme...