ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0015.10-21 | Prevention | ESPEYB15

10.21 Loss of intra-islet heparan sulfate is a highly sensitive marker of T1DM progression in humans

CJ Simeonovic , SK Popp , LM Starrs , DJ Brown , AF Ziolkowski , B Ludwig , SR Bornstein , JD Wilson , A Pugliese , TWH Kay , HE Thomas , T Loudovaris , FJ Choong , C Freeman , CR Parish

To read the full abstract: PLoS One. 2018;13:e0191360Up to now most studies to prevent autoimmune T1DM have focused on directly suppressing the autoimmune response rather than to better understanding the intrinsic requirements for beta cell survival. In this trial intracellular heparan sulfate was investigated as an essential requirement for the survival of beta cells and a marker for beta...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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