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ey0018.11-15 | New insight into preconceptional and prenatal programming | ESPEYB18

11.15. Sex-specific programming effects of parental obesity in pre-implantation embryonic development

K Hedegger , J Philippou-Massier , S Krebs , H Blum , S Kunzelmann , K Forstemann , M Gimpfl , AA Roscher , R Ensenauer , E Wolf , M Dahlhoff

Int J Obes (Lond). 2020 May;44(5):1185–1190. https://pubmed.ncbi.nlm.nih.gov/31776435/These authors investigated the effect of maternal and paternal obesity on gene expression level in the mouse blastocyst. Firstly, they show that female and male offspring were differentially sensitive to an obesogenic maternal environment in the early phase of preimplantation. Male blastocysts from o...

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ey0021.14-7 | Epi-/Genetics | ESPEYB21

14.7. Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs

Tomar A. , Gomez-Velazquez M. , Gerlini R. , Comas-Armangue G. , Makharadze L. , Kolbe T. , Boersma A. , Dahlhoff M. , Burgstaller J.P. , Lassi M. , Darr J. , Toppari J. , Virtanen H. , Kuhnapfel A. , Scholz M. , Landgraf K. , Kiess W. , Vogel M. , Gailus-Durner V. , Fuchs H. , Marschall S. , de Angelis M. Hrabě , Kotaja N. , Korner A. , Teperino R.

Brief Summary:This study in mice and humans shows how paternal overweight at conception affects the metabolism of their offspring. Sperm-borne mt-sncRNAs (mitochondrial encoded or derived small non-coding RNAs) are altered by a 2-week high fat diet (HFD) challenge in mice, likely through specific upregulation of mt-tsRNAs (mitochondrial transfer RNAs) caused by mitochondrial dysfunction. In humans, mt-tsRNAs in spermatozoa correlate with body mass index. Genetically engineered...

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ESPE Yearbook of Paediatric Endocrinology

11.15. Sex-specific programming effects of parental obesity in pre-implantation embryonic development

14.7. Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs

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