ESPE Yearbook of Paediatric Endocrinology

The adrenal cortex and medulla are intimately linked both anatomically and functionally in the adrenal gland (1, 2). Glucocorticoids are essential for the survival and maintenance of chromaffin cells, as well as the production of epinephrine (3, 4). At the transcriptional level, the expression of phenylethanolamine N-methyltransferase (PNMT), the enzyme that converts norepinephrine to epinephrine, depends on glucocorticoids (5...