ISSN 1662-4009 (online)

ey0021.4-11 | New Mechanisms | ESPEYB21

4.11. Lower muscle protein synthesis in humans with obesity concurrent with lower expression of muscle IGF1 splice variants

EDS Freitas , KA Kras , LR Roust , EA De Filippis , SR Kimball , M Buras , CS Katsanos

Brief Summary: This cross-sectional study explored the relationship between obesity and skeletal muscle protein synthesis, focusing on the expression of IGF-I and its mRNA splice variants. It provides insights into how obesity might impair protein synthesis and IGF-I levels, potentially contributing to the reduced muscle quality observed in obese patients.This study explored IGF-I expression in the muscles of obese patients as a potential factor contribu...