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ey0018.8-9 | Clinical Trials – New Treatments | ESPEYB18

8.9. Efficacy and safety of osilodrostat in patients with Cushing's disease (LINC 3): a multicentre phase III study with a double-blind, randomised withdrawal phase

R Pivonello , M Fleseriu , J Newell-Price , X Bertagna , J Findling , A Shimatsu , F Gu , R Auchus , R Leelawattana , EJ Lee , JH Kim , A Lacroix , A Laplanche , P O'Connell , L Tauchmanova , AM Pedroncelli , BMK Biller

Lancet Diabetes Endocrinol. 2020; 8(9): 748761.https://pubmed.ncbi.nlm.nih.gov/32730798/The authors report the outcomes from the pivotal phase 3 trial in patients with Cushings disease of osilodrostat (a potent oral inhibitor of cytochrome P450 11B1, [mitochondrial 11β-hydroxylase]). Twice-daily osilodrostat rapidly reduced mean 24-h urine free cortisol (UFC) and sustained ...

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ey0021.15-10 | Artificial Intelligence | ESPEYB21

15.10. A foundation model for generalizable disease detection from retinal images

Y Zhou , MA Chia , SK Wagner , MS Ayhan , DJ Williamson , RR Struyven , T Liu , M Xu , MG Lozano , P Woodward-Court , Y Kihara , UKB Eye , C Vision , A Altmann , AY Lee , EJ Topol , AK Denniston , DC Alexander , PA. Keane

In Brief: The authors present RETFound, a self-supervised learning approach that has so far analysed 1.6 million retinal images to enable disease detection. RETFound shows good accuracy for diagnosis and prognosis of sight-threatening eye diseases. It also contributes to incident prediction of complex systemic disorders such as heart failure and myocardial infarction.The well-known saying the eyes are the window to the soul means ...

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ESPE Yearbook of Paediatric Endocrinology

8.9. Efficacy and safety of osilodrostat in patients with Cushing's disease (LINC 3): a multicentre phase III study with a double-blind, randomised withdrawal phase

15.10. A foundation model for generalizable disease detection from retinal images

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