ESPE Yearbook of Paediatric Endocrinology

Pediatric diabetes 2021;22(7):946-50. doi: 10.1111/pedi.13254Brief Summary: This retrospective study describes the characteristics of 35 prepubertal children diagnosed with T2DM during 2016–2019 in Houston, Texas. These children had severe obesity, insulin resistance and dyslipidemia.Comment: We were all appalled when the first incidence of T2DM in a 5-year-old girl was...

To read the full abstract: J Pediatr 2018;196:208-216.e2Insulin deficiency or resistance activates intracellular hormone-sensitive lipase; this increases the release of non-esterified fatty acids from triglycerides stored in centrally distributed adipose tissue. High circulating levels of non-esterified fatty acids increase hepatic triglyceride synthesis, which in turn increases secretion o...