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ey0017.6-4 | Differences/Disorders of Sex Development: Basic Research | ESPEYB17

6.4. Dynamics of the transcriptional landscape during human fetal testis and ovary development

E Lecluze , AD Rolland , P Filis , B Evrard , S Leverrier-Penna , MB Maamar , I Coiffec , V Lavoue , PA Fowler , S Mazaud-Guittot , B Jegou , F Chalmel

To read the full abstract: Hum Reprod. 2020, May 15; 10.1093/humrep/deaa041. doi: https://academic.oup.com/humrep/articleabstract/35/5/1099/5837511This study provides a comprehensive reference of the protein-coding and non-coding genome from 24 testes and 24 ovaries of human fetuses. It used an RNA sequencing approach to investigate non-coding sequences, and to ident...

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ey0021.6-1 | DSD - Novel Genes and Mechanisms involved in Gonadal Development | ESPEYB21

6.1. The -KTS splice variant of WT1 is essential for ovarian determination in mice

EP Gregoire , MC De Cian , R Migale , A Perea-Gomez , S Schaub , N Bellido-Carreras , I Stevant , C Mayere , Y Neirijnck , A Loubat , P Rivaud , ML Sopena , S Lachambre , MM Linssen , P Hohenstein , R Lovell-Badge , S Nef , F Chalmel , A Schedl , MC Chaboissier

Brief Summary: This study examined the complex process of sex determination in mice, with a specific focus on the role of WT1 isoforms, +KTS and -KTS, during gonadal development. The study provides insights into how the balance between these isoforms impacts sexual differentiation, with broader implications for understanding gonadal dysgenesis conditions, like Frasier syndrome.While the role of the SRY gene in testicular determination i...

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ESPE Yearbook of Paediatric Endocrinology

6.4. Dynamics of the transcriptional landscape during human fetal testis and ovary development

6.1. The -KTS splice variant of WT1 is essential for ovarian determination in mice

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