ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0020.9-4 | New Findings in Adipose Tissue | ESPEYB20

9.4. SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression

T Villanueva-Carmona , L Cedo , A Madeira , V Ceperuelo-Mallafre , M Rodriguez-Pena , C Nunez-Roa , E Maymo-Masip , M Repolles-de-Dalman , J Badia , N Keiran , M Mirasierra , C Pimenta-Lopes , J Sabadell-Basallote , R Bosch , L Caubet , JC Escola-Gil , JM Fernandez-Real , N Vilarrasa , F Verntura , M Vallejo , J Vendrell , S Fernandez-Veledo

Brief summary: Villanueva-Carmona et al. identified succinate as a mediating metabolite in leptin secretion. Its action is mediated by the succinate receptor SUCNR in adipocytes via the circadian clock in an AMPK/JNK-C/EBPa-dependent manner.Although the regulatory circuits of leptin action on hunger and satiety are well understood, the pathways that mediate acute leptin production in the adipose tissue are less investigated. To investigate how a...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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