ISSN 1662-4009 (online)

ey0021.3-3 | Hypothalamus-Pituitary-Axis Regulation | ESPEYB21

3.3. TSH pulses finely tune thyroid hormone release and TSH receptor transduction

Guillou Anne , Kemkem Yasmine , Lafont Chrystel , Fontanaud Pierre , Calebiro Davide , Campos Pauline , Bonnefont Xavier , Fiordelisio-Coll Tatiana , Wang Ying , Brule Emilie , Bernard Daniel J , Tissier Paul Le , Steyn Frederik , Mollard Patrice

Brief Summary: This study examined the pulsatile secretion of TSH and its regulatory role in thyroid hormone (TH) synthesis in mice. Using a novel ultra-sensitive ELISA for mouse TSH, it shows that TSH pulsatility plays a critical role in regulating thyroid function.In addition to mapping the normal TSH secretion pattern in healthy mice, and the secretion pattern in a mouse model of disease (mouse made hypothyroid by an iodine-deficient diet enriched wit...