ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This review summarizes the role of macronutrients and hormones which regulate energy balance and sexual maturation by conveying energy availability information to the GnRH system.30 years ago, Kennedy and Mitra were the first to use translational studies to show that nutrition is a key factor regulating puberty timing1. Their seminal protocol modified the size of rat litters to affect weight increase and showed that nutritional ...