ISSN 1662-4009 (online)

ey0021.10-15 | New Biomarkers | ESPEYB21

10.15. Stress-induced beta cell early senescence confers protection against type 1 diabetes

H Lee , GS Sahin , CW Chen , S Sonthalia , SM Canas , HZ Oktay , al. et

Brief Summary: This experimental study unveiled a new link between the β-cell unfolded protein response and senescence. Deletion of the genes Atf6α or Ire1α in β-cells of non-obese diabetic (NOD) mice prior to insulitis generated a p21-driven early senescence phenotype, which altered the β-cell secretome and promoted protective M2 macrophages recruitment to pancreatic islets. M2 macrophages induced immune surveillance and removal of t...