ESPE Yearbook of Paediatric Endocrinology

Brief Summary: This article reports a successful medical trial to test the therapeutic potential of targeting the BRAF-MEK pathway (using vemurafenib-cobimetinib combination therapy) in 16 patients with newly diagnosed papillary craniopharyngiomas (PCPs).The authors recruited 16 patients with PCP who tested positive for BRAFV600E mutation, had not undergone radiation therapy and had measurable disease. The primary endpoint was objective respons...

To read the full abstract: Diabetes Care. 2018;41:311-317Some researchers assume that the etiology of T1DM is distinct from that of Type 2 diabetes mellitus. T1DM is characterized by autoimmune phenomena leading to the destruction of pancreatic islets and most importantly of beta-cells. Genetic factors are thought to influence the likelihood of autoimmune phenomena developing into overt autoimmune di...