ISSN 1662-4009 (online)

ey0021.6-9 | New Clinical Insights into Klinefelter Syndrome | ESPEYB21

6.9. Executive dysfunction in Klinefelter syndrome: associations with brain activation and testicular failure

LC Foland-Ross , E Ghasemi , V Lozano Wun , T Aye , K Kowal , J Ross , AL Reiss

Brief Summary: This clinical cross-sectional study provides new data on the neurodevelopmental aspects of Klinefelter syndrome (KS). It investigated the brain activation patterns in 43 adolescent males with KS (mean age 12.3±2.3 years) compared to an age-matched typically-developing (n=41) control group during the go/no-go task, an executive function assessment. Behavioral assessment tests, and functional magnetic resonance imaging (fMRI) were used....