ESPE Yearbook of Paediatric Endocrinology

iScience. 2021 Oct 11;24(11):103257. PMID: 34761181, doi: 10.1016/j.isci.2021.103257.Brief Summary: The authors explored the relationship between sex hormones and lipids in pre-pubertal children, young post-pubertal cisgender men and women, and transgender adolescents on gender affirming hormone (GAH) tre...

Brief summary: This study further explores the sex differences in autoimmune regulation and the control of normal inflammatory responses, and also helps us understand why there are sex differences in the aetiology of autoimmune diseases such as systemic lupus erythematosus (SLE). It demonstrates the changes that occur in cisgender pubertal development on the T regulatory cell (Treg), B cell and monocyte population, and using samples from transgender adolescents undergoing GnRH...

Nat Commun. 2020 Aug 13;11(1):4063. doi: 10.1038/s41467-020-17890-2. PMID: 32792525.These researchers proposed the heterogeneity of hypothalamic neural progenitor cells. Other than traditional hypothalamic radial glial (hRG) cells, which are predominantly located in the ventricular zone, there are additional basal progenitors in the mantle zone, which are named as hypothalamic mantle zo...