ISSN 1662-4009 (online)

ey0021.7-10 | Basic Research | ESPEYB21

7.10. Changes in the bile acid pool and timing of female puberty: potential novel role of hypothalamic TGR5

H Vanden Brink , D Vandeputte , IL Brito , OK Ronnekleiv , MS Roberson , A Lomniczi

Brief Summary: This translational study identifies significant shifts in bile acid composition associated with puberty in female adolescents and rats and identifies a new mechanism of GnRH secretion regulation by bile acid.Metabolic cues regulate the reactivation of the GnRH system at puberty. The last few years have identified leptin, ghrelin and essential fatty acids as permissive or inhibitory cues regulating GnRH neuron activity1-4. The ef...